GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4357530 | 1 | rs6674970 | chr1:151116279 | BNIPL | chr1:151009029-151020076:+ | -0.18 | -3.79 | 0.000172 | Body mass index |
| THCA | cis | rs8170 | 1 | rs66753001 | chr19:17394839 | ABHD8 | chr19:17402941-17414282:- | 0.26 | 4.18 | 3.47E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs66753001 | chr19:17394839 | ANKLE1 | chr19:17392454-17398454:+ | 0.3 | 5.01 | 7.69E-7 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs66753001 | chr19:17394839 | OCEL1 | chr19:17337055-17340027:+ | 0.21 | 4.04 | 6.31E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs6138150 | 1 | rs66754062 | chr20:23839051 | CST5 | chr20:23856572-23860380:- | 0.13 | 3.48 | 0.000543 | Response to TNF antagonist treatment |
| THCA | cis | rs2275426 | 1 | rs6675726 | chr1:46560643 | CCDC163P | chr1:45960581-45965646:- | -0.52 | -10.17 | 4.03E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6675726 | chr1:46560643 | GPBP1L1 | chr1:46092978-46152302:- | 0.13 | 3.41 | 0.000705 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6675726 | chr1:46560643 | MMACHC | chr1:45965856-45976737:+ | -0.21 | -4.48 | 9.32E-6 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6675726 | chr1:46560643 | MUTYH | chr1:45794915-45806142:- | 0.28 | 7.49 | 3.29E-13 | Body mass index |
| THCA | cis | rs6675828 | 1 | rs6675828 | chr1:147086967 | ACP6 | chr1:147119168-147142634:- | 0.24 | 3.81 | 0.000159 | Warfarin maintenance dose |
| THCA | cis | rs2275426 | 1 | rs6675946 | chr1:46371774 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -9.9 | 3.85E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6675946 | chr1:46371774 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.57E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6675946 | chr1:46371774 | MMACHC | chr1:45965856-45976737:+ | -0.2 | -4.36 | 1.56E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6675946 | chr1:46371774 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.51 | 2.27E-16 | Body mass index |
| THCA | cis | rs4357530 | 1 | rs6676190 | chr1:151079317 | BNIPL | chr1:151009029-151020076:+ | -0.17 | -3.59 | 0.000371 | Body mass index |